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Drug Name: | Ativan (Generic) |
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Ativan – A Drug with Anxiolytic, Muscle Relaxant, Anticonvulsant, and Hypnotic Effects
Prescription medications known as benzodiazepines help treat anxiety, insomnia, and control seizures. These substances have a calming effect on the central nervous system, leading to a decrease in body and brain activity, as well as drowsiness and muscle relaxation. Benzodiazepines include such active ingredients as Alprazolam, Bromazepam, Diazepam, Clonazepam, Lorazepam, etc. They differ in exposure time and potential side effects. Lorazepam (trade name Ativan) is one of the most common today due to its rapid effect and higher safety compared to other drugs in this group.
How Does Ativan Work?
Ativan produces a strong soothing impact on the CNS and causes muscle relaxation. It also has anticonvulsant and mild hypnotic effects. Reduces fear, anxiety, tension.
Indications and Contraindications
Main indications: • neurotic conditions accompanied by anxiety, agitation, tension, increased irritability, insomnia; • functional cardiovascular neuroses, gastrointestinal neuroses, migraine, and menopausal disorders; • diseases with symptoms of obsession, anxiety, fear, tension; • depressive and hypochondriacal conditions; • epilepsy; • alcohol withdrawal syndrome. The drug has also found application in anesthesiology. It is used for preoperative sedation to alleviate anxiety and induce a calm effect before surgery and other painful medical interventions. But it is important to consider contraindications: • hypersensitivity to benzodiazepines; • myasthenic syndrome; • glaucoma (closed-angle form); • acute intoxication with psychotropic drugs that depress the central nervous system; • respiratory depression; • renal and liver failure; • pregnancy (especially the first trimester), lactation period.
Ativan Recommended Dosages and Administration Features
Ativan pills should be taken orally with a sufficient amount of water. The recommended dosage is 1–2 mg (up to 2.5 mg if necessary) 2-3 times a day. In case of insomnia – 1-4 mg half an hour before bedtime. Pre-anesthesia medication dosage for adults is 2.5–5 mg, while for children it is 0.05 mg/kg. With prolonged use and exceeding dosages, drug addiction may occur. After administration, the drug is quickly absorbed from the gastrointestinal tract. Bioavailability is 90%. Maximum concentration in blood plasma is achieved within 1-3 hours. Ativan undergoes liver metabolism primarily through oxidation with the formation of both active and inactive metabolites, which actually provide its long-lasting and pronounced effects. The half-life varies between 6 and 24 hours. The active substance and its metabolites are excreted mainly by the kidneys with urine, a small part through the intestines. Using Ativan at the same time as other CNS depressants can intensify their inhibitory impact and cause acute poisoning. The medication boosts the effects of pain relievers, sleep aids, sedatives, and allergy medications. It also potentiates the effect of general and local anesthetics. The combination of Ativan (Lorazepam) with alcohol can potentially cause pathological intoxication, psychomotor agitation, and aggressive behavior. The likelihood of acute intoxication increases, which can have serious health consequences.
What Are The Potential Side Effects of Ativan?
Just like with any other medication, Ativan can lead to adverse reactions such as sleepiness, tiredness or overall weakness, dizziness, decreased breathing rate, sight loss, bowel issues, headache, dry mouth, and difficulty urinating. Nevertheless, the risk of side effects is small if you strictly follow the doctor's recommendations during treatment.
Tips to Follow During Ativan Treatment
Lorazepam has a high addictive potential, so should be taken with extra caution. Use it in short treatment cycles. Gradually decrease the dose before stopping the medication. Here are some more useful tips: 1. Use strictly according to indications, under the supervision of a specialist. 2. Before starting treatment, consider contraindications, possible risks, and side effects. 3. If unpleasant symptoms appear, consult a doctor immediately. 4. It is forbidden to adjust the dose yourself. Be sure to follow the above tips when using Ativan. This way you will receive treatment with maximum health benefits and no adverse effects.